PNS211 ASSESSING POPULATION-ADJUSTED INDIRECT COMPARISON METHODS (MATCHING-ADJUSTED INDIRECT COMPARISON AND SIMULATED TREATMENT COMPARISON) USING MONTE-CARLO SIMULATIONS
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چکیده
منابع مشابه
Matching-adjusted indirect comparison of adalimumab vs etanercept and infliximab for the treatment of psoriatic arthritis.
OBJECTIVES No head-to-head trial has compared the efficacy of adalimumab vs etanercept and infliximab for psoriatic arthritis (PsA). This study implements a matching-adjusted indirect comparison technique to address that gap. METHODS Patient-level data from a placebo-controlled trial of adalimumab (ADEPT) were re-weighted to match average baseline characteristics from pivotal published trials...
متن کاملA systematic review and adjusted indirect comparison of oral anticoagulants.
EDUCATIONAL OBJECTIVES As a result of reading this article, physicians should be able to: 1. Recognize the high risk of postoperative venous thromboembolism (VTE) in patients undergoing major orthopedic surgery. 2. Distinguish the different pharmacological mechanisms of VTE prophylaxis drugs. 3. Delineate the advantages and disadvantages of each VTE prophylaxis drug. 4. Recognize that rivaroxab...
متن کامل228-2011: Matching-Adjusted Indirect Comparison Analysis Using Common SAS® 9.2 Procedures
This paper presents a novel matching-adjusted approach to indirectly compare survival estimates for competitive treatment options. Using patient-level data for the treatment arm and summary patient characteristics and survival outcomes for the comparator, matching variables prognostic for survival are chosen. A program involving an extension of a common SAS® 9.2 procedure, PROC SURVEYSELECT, is...
متن کاملA Matching-Adjusted Indirect Comparison of Sonidegib and Vismodegib in Advanced Basal Cell Carcinoma
OBJECTIVES Based on single-arm trial data (BOLT), sonidegib was approved in the US and EU to treat locally advanced basal cell carcinomas (BCCs) ineligible for curative surgery or radiotherapy. Vismodegib, the other approved targeted therapy, also was assessed in a single-arm trial (ERIVANCE). We examined the comparative effectiveness of the two drugs using a matching-adjusted indirect comparis...
متن کاملEverolimus and sunitinib for advanced pancreatic neuroendocrine tumors: a matching-adjusted indirect comparison
BACKGROUND Everolimus and sunitinib have been approved for the treatment advanced pancreatic neuroendocrine tumors, but have not been compared to each other in a randomized trial and have not demonstrated prolonged overall survival compared to placebo. This study aimed to indirectly compare overall and progression-free among everolimus, sunitinib and placebo across separate randomized trials. ...
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ژورنال
عنوان ژورنال: Value in Health
سال: 2019
ISSN: 1098-3015
DOI: 10.1016/j.jval.2019.04.1568